谁能给我翻译一下"痛不欲生”的英语

这个有不同的词或词组可以表示这个意思啊，没有一个固定的词组，比如下面几个例子：

Mark beat his breast in agony.
马克捶胸顿足，痛不欲生。

inconsolable when her son died.
儿子死时她痛不欲生。

She is inconsolable for the loss of her husband.
她因失去丈夫而痛不欲生[忧伤不已]。

Ever since her son died, the poor woman has been eating her heart out.
自从儿子死后，这位可怜的妇女万分悲伤，痛不欲生。

eat one's heart 痛不欲生